Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length495 amino acids

Chemical FormulaC2436H3865N627O706S16

DescriptionStandard

        MSLWCVTVALLGLLTPALSTDPGVIVQLTQQGLEYGRQIGIASLQQKLNSIKIPDISGSEDVSPIGKVEYSLSQMHITNLGLPASSLGLVPGSGLSLSISDAFISLNGHWHVKYLKFIKDSGSFDLTVSGLTISVTMGVNSDETGRPTVSSSNCAASVGHVSIEFHGGKTSALRFVAFGHRICPLVHDAISDINPHLKTMNVLAQVDKYAEIEYSLVTSPVVSNTFIQFSLKGEFYKIGQHQEPPFSAPPFSLPQTNGSMLYLGLSSFIANSAGFVYHNAGVLGLYVTDDMIPSSSPLRLNTKTFGAFIPEIAKRFPNMMMKLLVKTLEPPRITFEPNNVTLQANGTVTAYAILPNNTLEALFILNLEASVSAELHVSGLNIAGSVTLNSMTLGTSYVGQFQVMPLNNIFTMILKVVVIPKVNEKLQQGYPLPAISHMNLVNTQLKVLKVKRNKSKKGYQQALLVLNKNYIQEVVTLNGFWLWIYATDLRGNDTL
    

Molecular Weight53744.56 Da

Isoelectric Point (pI)8.53

Net Charge (pH 7.0)3.54

Net Charge (pH 7.4) 2.58

Charge Density (pH 7.0) 0.0072

GRAVY Index0.19

Hydrophobic Moment 0.70

Boman Index0.19

Instability Index36.24

Aliphatic Index 105.11

Aromaticity 0.0808

Extinction Coeff. Reduced 44350.00

Extinction Coeff. Oxidized 44475.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0292094 VERIFIED: NO

Provenance & Taxonomy

OrganismScleropages formosus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence