Peptide Database

Peptide NameBelantamab mafodotin

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Immunomodulation ▸ Immuno-oncology

Standard StatusStandard

Sequence Length451 amino acids

Chemical FormulaC2199H3406N586O678S16

DescriptionStandard

        QVQLVQSGAEVKKPGSSVKVSCKASGGTFSNYWMHWVRQAPGQGLEWMGATYRGHSDTYYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARGAIYDGYDVLDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
    

Molecular Weight49413.13 Da

Isoelectric Point (pI)8.58

Net Charge (pH 7.0)6.63

Net Charge (pH 7.4) 5.58

Charge Density (pH 7.0) 0.0147

GRAVY Index-0.44

Hydrophobic Moment 0.58

Boman Index0.00

Instability Index42.64

Aliphatic Index 68.18

Aromaticity 0.0931

Extinction Coeff. Reduced 80790.00

Extinction Coeff. Oxidized 81415.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0025980 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMonoclonal antibody

Tax ID32630

Structure & Mods

Configcyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory Immuno-oncology

Half-LifeThe terminal half life of belantamab mafodotin was 12 days after the first dose and 14 days at steady state.[L15326]