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MYP_035161
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Basic Information
Caerin 1.6
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C124H205N31O29
Standard
Sequence
GLFSVLGAVAKHVLPHVVPVIAEKL
Physicochemical Analysis
2594.14 Da
8.61
0.94
0.63
0.0374
1.22
0.43
0.47
25.92
159.60
0.0400
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
911.07
-3.18
30.0
32.0
81.0
184.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0403721 VERIFIED: YES
Provenance & Taxonomy
Ranoidea chloris [Animal]
Frog skin active peptide (FSAP); Caerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Non-hemolytic
PMID9516047;11784303 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9516047/
RECORD: Rec_0407007 VERIFIED: NO
Provenance & Taxonomy
Litoria xanthomera [Animal]; Litoria chloris [Animal]; Litoria caerulea [Animal]; Litoria rothii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0416709 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Caerin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Anticancer nNOS inhibitor
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
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