‹ ›
MYP_035104
← PREVIOUS NEXT → BACK
Basic Information
ALLN
Antimicrobial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Enzyme modulation ▸ Enzyme inhibition ▸ Proteasome inhibitor
not Standard
3 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
LLX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0350059 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Protease/Proteasome inhibitor
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
None
Norleucinal (Nle)
Bio-Activity Profile
Antimicrobial Proteasome inhibitor Antiparasitic Antimalarial
Plasmodium falciparum 3D7 parasite line
72.4±7.8 μM
IC50; [3H] Hypoxanthine incorporation assay
PaperRole of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors PMID19752273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19752273/
RECORD: Rec_0355071 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 0.0%, C 100.0% [Linear]
residue-level stereochemical modification [Mixed]
Acetylation
None
Nle=Norleucinal
Bio-Activity Profile
Antiparasitic Antimicrobial Antiplasmodial Proteasome inhibitor
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0360554 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Protease/Proteasome inhibitor
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
None
Norleucinal (Nle)
Bio-Activity Profile
Antimicrobial Proteasome inhibitor Antiparasitic Antimalarial
Plasmodium falciparum GC03 parasite line
97.9±10.3 μM
IC50; [3H] Hypoxanthine incorporation assay
PaperRole of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors PMID19752273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19752273/
RECORD: Rec_0403602 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Protease/Proteasome inhibitor
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
None
Norleucinal (Nle)
Bio-Activity Profile
Antimicrobial Proteasome inhibitor Antiparasitic Antimalarial
Plasmodium falciparum Δpfpm4 parasite line
84.5±14.3 μM
IC50; [3H] Hypoxanthine incorporation assay
PaperRole of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors PMID19752273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19752273/
RECORD: Rec_0419004 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Protease/Proteasome inhibitor
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
None
Norleucinal (Nle)
Bio-Activity Profile
Antimicrobial Proteasome inhibitor Antiparasitic Antimalarial
Plasmodium falciparum Δpfpm2 parasite line
86.4±9.8 μM
IC50; [3H] Hypoxanthine incorporation assay
PaperRole of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors PMID19752273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19752273/
FIRST PREV 1 2
Showing 5 records on this page · Page 2 of 2