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MYP_034993
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Basic Information
Ala50 substitution mutant of Tat (49-57)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
9 amino acids
C50H99N29O11
Standard
Sequence
RAKRRQRRR
Physicochemical Analysis
1282.51 Da
12.00
6.76
6.55
0.7510
-3.62
0.62
-1.88
257.44
11.11
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
736.63
-9.73
30.0
18.0
48.0
90.0
0.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0139310 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Fluorescein/FITC labeling
None
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PaperThe design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters PMID11087855 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087855/
RECORD: Rec_0142384 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Fluorescein/FITC labeling
None
N-term detail: Labelled with fluorescein with aminohexanoic space
Bio-Activity Profile
Cell-penetrating peptide
Jurkat
Fluorescence-based uptake assay
PMID11087855 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087855/
RECORD: Rec_0147586 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
fluorescein with 6-aminohexanoic acid (Ahx) spacer
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID11087855 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087855/
RECORD: Rec_0163398 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
fluorescein with 6-aminohexanoic acid (Ahx) spacer
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID11087855 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087855/
RECORD: Rec_0372452 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Labelled with fluorescein with aminohexanoic space
None
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
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