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MYP_034989
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Basic Information
Pxt‐12(CPF-St7)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
18 amino acids
C83H150N22O24
Standard
Sequence
NLLGSLLKTGLKVGSNLL
Physicochemical Analysis
1840.21 Da
10.00
1.76
1.55
0.0977
0.69
0.57
0.28
-14.14
167.78
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
756.93
-7.11
26.0
26.0
65.0
129.0
0.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0324466 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Staphylococcus aureus ATCC 25923
32 μM
MIC
PMID23935531;26802742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0335281 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic Toxicity
not hemo.lytic: Toxicity to erythrocytes
256 μM
HC50
PaperOrigin and functional diversification of an amphibian defense Peptide arsenal. PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0353276 VERIFIED: YES
Provenance & Taxonomy
African clawed [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23935531/
RECORD: Rec_0360269 VERIFIED: NO
Provenance & Taxonomy
Xenopus tropicalis [Animal]; Silurana tropicalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Hemolytic
RECORD: Rec_0363458 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
Hemolysis against Mouse erythrocytes
256 μM
IC50
PMID26802742;23935531 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26802742/
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