Peptide Database

Peptide NamePxt‐12(CPF-St7)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxicity

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC83H150N22O24

DescriptionStandard

        NLLGSLLKTGLKVGSNLL
    

Molecular Weight1840.21 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.0977

GRAVY Index0.69

Hydrophobic Moment 0.57

Boman Index0.28

Instability Index-14.14

Aliphatic Index 167.78

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 756.93

LogP -7.11

H-bond Donors 26.0

H-bond Acceptors 26.0

Rotatable Bonds 65.0

Heavy Atoms 129.0

Ring Count 0.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0030676 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic

RECORD: Rec_0035447 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetPseudomonas aeruginosa NBRC 12582

Activity50 μM

MethodMIC

RECORD: Rec_0056746 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetGram-negative bacteria: Escherichia coli ATCC 25922

Activity128 μM

MethodMIC

RECORD: Rec_0063617 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetParasite:Trypanosoma brucei(LC95=2-64 μM)

RECORD: Rec_0063804 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 38.9%, E 0.0%, T 16.7%, C 44.4% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antibacterial Antiparasitic Toxic Antimicrobial Antifungal Cytotoxic Anti-Gram-negative

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