Peptide Database

Peptide Nameepiregulin

Function Ontology

Immunology ▸ Immune modulation ▸ Cytokine modulation

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Signaling peptide

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length49 amino acids

Chemical FormulaC239H365N65O73S8

DescriptionStandard

        VAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFL
    

Molecular Weight5573.37 Da

Isoelectric Point (pI)6.01

Net Charge (pH 7.0)-1.15

Net Charge (pH 7.4) -1.56

Charge Density (pH 7.0) -0.0234

GRAVY Index0.11

Hydrophobic Moment 0.53

Boman Index0.10

Instability Index6.91

Aliphatic Index 71.43

Aromaticity 0.1224

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2234.25

LogP -23.37

H-bond Donors 84.0

H-bond Acceptors 82.0

Rotatable Bonds 181.0

Heavy Atoms 385.0

Ring Count 8.0

Amide Bonds 53.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0110201 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsDisulphide bond formation between cysteine residues at positions 9 and 22, 17 and 33, and 35 and 44

Bio-Activity Profile

Function

Immunomodulatory Signaling peptide

Targetepidermal growth factor receptor (Human); erb-b2 receptor tyrosine kinase 4 (Human)

RECORD: Rec_0340446 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Signaling peptide Cell-cell communication Cytokine activity

Targetcell-cell communication; cytokine signaling