Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length490 amino acids

Chemical FormulaC2434H3892N646O683S18

DescriptionStandard

        KGGMARGPDSMPQWAILVVLTTMGTAATAATNPGLLTRISQKGLDYACQKGVAMLQKELEKIKIPDFSGNFKIQHLGKGYYSFYSMTILGFQLPSPQIRLEPQVGLRLSISKANVKISGKWKGKKNFFSASGKFDLSIEGVSISAFLNLGSDPTSGHITVACSSCGSHISNTRLRIWGSTVGWLIQLFHKKIESSLRNTLNSKICKFVANSVSTKLQAYVKKFPVTTQIDAVAGIDYRLVAPPITTAENLDGQLKGEFFSQAHRSPPPFTPPAMAFPEDHDRMVYLGISDYFFNTAGLVYQEAGALKLTLQDHMMPNGSKFLLTTKSLGNVLPQVAKMFPNMKVQLQVSVSTPPQLNTQPTGLTLTPKLEVQAFVVLPNSSLVPLFLLSMVSRTASAALEVGARSNRLVGELQVDSRLILKLKRSNIGPFQVELLQTVMDYVVHTVLLPRVNEKLKTAFPLPMPARVQLYNLLLQSHQNFLQFGADVNLV
    

Molecular Weight53710.03 Da

Isoelectric Point (pI)9.78

Net Charge (pH 7.0)21.52

Net Charge (pH 7.4) 20.70

Charge Density (pH 7.0) 0.0439

GRAVY Index0.04

Hydrophobic Moment 0.65

Boman Index0.11

Instability Index39.41

Aliphatic Index 96.88

Aromaticity 0.0816

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38640.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0126392 VERIFIED: NO

Provenance & Taxonomy

OrganismIctidomys tridecemlineatus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria