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MYP_034919
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Basic Information
Pleurain-A2 (Pleurain A2; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C133H220N36O38S3
Standard
Sequence
SIITMTKEAKLPQSWKQIACRLYNTC
Physicochemical Analysis
3027.58 Da
9.30
2.44
2.20
0.0938
-0.23
0.54
-0.03
59.68
82.69
0.0769
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1225.73
-11.37
45.0
44.0
101.0
210.0
4.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0212899 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
20-26
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID17764786 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17764786/
RECORD: Rec_0222659 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic
C. albicans
30 μg/mL
MIC
RECORD: Rec_0228328 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anti-Gram-negative
Escherichia coli
60 μg/mL
MIC
RECORD: Rec_0232856 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
200000 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/17764786/ PMID17764786 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17764786/
RECORD: Rec_0242525 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
20-26
Bio-Activity Profile
Antimicrobial Antifungal
B. dysenteriae
60 μg/mL
MIC
PaperA new family of antimicrobial peptides from skin secretions of Rana pleuraden
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