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MYP_034919
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Basic Information
Pleurain-A2 (Pleurain A2; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C133H220N36O38S3
Standard
Sequence
SIITMTKEAKLPQSWKQIACRLYNTC
Physicochemical Analysis
3027.58 Da
9.30
2.44
2.20
0.0938
-0.23
0.54
-0.03
59.68
82.69
0.0769
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1225.73
-11.37
45.0
44.0
101.0
210.0
4.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001063 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
20-26
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus dysenteriae
60 μg/mL
MIC
PMID17764786 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17764786/
RECORD: Rec_0015729 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Toxic Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0020744 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
20-26
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus ATCC 2592
15 μg/mL
MIC
PMID17764786 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17764786/
RECORD: Rec_0034494 VERIFIED: YES
Provenance & Taxonomy
Nidirana pleuraden [Animal]
Pleurain
369511
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
20-26
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
19.84 μM
MIC
PaperX. Wang et al. / Peptides 28 (2007) 2069-2074. A new family of antimicrobial peptides from skin secretions of Rana pleuraden Evidence URLhttps://www.uniprot.org/uniprotkb/A8B5P0/entry
RECORD: Rec_0045878 VERIFIED: YES
Provenance & Taxonomy
Babina pleuraden [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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