Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length460 amino acids

Chemical FormulaC2261H3624N574O657S18

DescriptionStandard

        MFLCCWLGLVALIPTTLSTNPGVKVRLTEKGIEYGRQLGMAVIQQKLGSIKIPDFSGTEKVSPIGKVQYSLSNMHIVNVGLPKSSVDLVPGTGVTLSIGDAFISLNGNWRVKYLRIIKDSGSFDLDVNGLSIATTISIKSDETGRPAVSSDSCSATVGSAKVKFHGGASWLYNLFTTFIDKALRNALQKQICPLVADAVSDLNPQLKTLNVLAKVDKYAEIEYSMVSSPTVLKSLIDLSLKGEFYNIGKHQEPPFSPAAFNLPPQNNNMLYIGMSAFTVNSAAFVYNNAGVLSLSITDDMIPKSSPIRLNTKTFGAFIPQIAKQFPGLMMKLLVKTVKTPTLTFQPNNATVQAITTVTAFAIQPNSTLSPLFVLNLEASVSARMFVSEMKLAAAVTLNKMDLTLDKSYVGDFQVRSVFLYNNTQLAKGYPLPTIGKMKLMNTQLDVLKDYILIGTDVQFS
    

Molecular Weight49937.58 Da

Isoelectric Point (pI)9.28

Net Charge (pH 7.0)10.73

Net Charge (pH 7.4) 10.20

Charge Density (pH 7.0) 0.0233

GRAVY Index0.17

Hydrophobic Moment 0.72

Boman Index0.16

Instability Index31.27

Aliphatic Index 101.28

Aromaticity 0.0826

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0036420 VERIFIED: NO

Provenance & Taxonomy

OrganismMaylandia zebra [Bacterium]

FamilyBPI

Tax ID106582

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence