Peptide Database

Peptide NameSLAY-screened peptide P5165

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC52H81N13O15S

DescriptionStandard

        PTFCALAHLTS
    

Molecular Weight1160.34 Da

Isoelectric Point (pI)7.12

Net Charge (pH 7.0)0.04

Net Charge (pH 7.4) -0.09

Charge Density (pH 7.0) 0.0033

GRAVY Index0.86

Hydrophobic Moment 0.19

Boman Index0.39

Instability Index12.59

Aliphatic Index 89.09

Aromaticity 0.0909

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 429.70

LogP -4.30

H-bond Donors 17.0

H-bond Acceptors 17.0

Rotatable Bonds 33.0

Heavy Atoms 81.0

Ring Count 3.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0246351 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/