Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length462 amino acids

Chemical FormulaC2276H3652N572O656S21

DescriptionStandard

        VTAVKMSPCCWLALLALVPLTLATNPGVKVKLTEKGIEYGKQIGMASLQQKLKTMKVPDLSGTERVAPIGKVKYSLTGMTIVNLGLPKSALALVPSTAISLTITNAFISLHGNWKIRYLSFIKDSGSFDLEVNGLTITDSITMKSDETGRPTVSSVNCVANVGSASIKFHGGASWLYNLFSAYIDKALRSALQKQICPLVADAITDMNPHLKTLNVLAKVDKYAEVQYSMVTSPTISNSSIDFSLKGEFYNIGKHQEPPFSPTPFSLPPQVNNILYIGISAFTINSAGFVYNNAGALSFYITDDMIPPSSPIRLNTRTFGALIPEIAKRFPGMMMKLLVKTVKEPTIFFEPNNVTVQASGTVTAYAIQTNTTLSPLFVLNMEGSVSARLYVTGMKLAGAVTLNKIEMTLETTYVGQFQVRSLDNIFLMVLKVAVIPKMNLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight50198.15 Da

Isoelectric Point (pI)9.28

Net Charge (pH 7.0)11.05

Net Charge (pH 7.4) 10.48

Charge Density (pH 7.0) 0.0239

GRAVY Index0.23

Hydrophobic Moment 0.70

Boman Index0.18

Instability Index32.01

Aliphatic Index 101.69

Aromaticity 0.0823

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0129482 VERIFIED: NO

Provenance & Taxonomy

OrganismCoregonus sp. `balchen` [Bacterium]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria