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MYP_034650
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Basic Information
Brevinin-2Tc
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
29 amino acids
C150H244N40O36S2
Standard
Sequence
GLWETIKNFGKKFTLNILHKLKCKIGGGC
Physicochemical Analysis
3247.92 Da
9.79
4.82
4.53
0.1664
-0.07
0.69
0.09
36.47
94.14
0.1034
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1242.65
-8.36
45.0
44.0
114.0
228.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0020607 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-29
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://www.uniprot.org/uniprotkb/P82234/entry
RECORD: Rec_0058604 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PMID10333736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10333736/
RECORD: Rec_0101678 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0122386 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0153774 VERIFIED: NO
Provenance & Taxonomy
Rana temporaria [Animal]
Frog skin active peptide (FSAP)
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal
Gram-negative bacteria; Gram-positive bacteria
Qualitative functional evidence
PMID10333736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10333736/; https://www.uniprot.org/uniprotkb/P82234/entry; https://bblserver.org.in/ampdb/
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