Peptide Database

Peptide NamesHR2-5(derived from SARS-CoV spike protein heptad repeat)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length48 amino acids

Chemical FormulaC227H375N61O82

DescriptionStandard

        TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE
    

Molecular Weight5270.77 Da

Isoelectric Point (pI)4.21

Net Charge (pH 7.0)-6.58

Net Charge (pH 7.4) -6.79

Charge Density (pH 7.0) -0.1371

GRAVY Index-0.38

Hydrophobic Moment 0.70

Boman Index-0.02

Instability Index35.55

Aliphatic Index 117.71

Aromaticity 0.0208

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2358.20

LogP -25.69

H-bond Donors 77.0

H-bond Acceptors 76.0

Rotatable Bonds 184.0

Heavy Atoms 370.0

Ring Count 2.0

Amide Bonds 54.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0374307 VERIFIED: YES

Provenance & Taxonomy

OrganismSevere acute respiratory syndrome-related coronavirus [Virus]

FamilyVirus-derived peptide

Tax ID694009;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetSARS coronavirus (Fusion); Vero

Activity50 μM

MethodEC50

PaperSevere acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. | Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ. | Proc Natl Acad Sci U S A. 2004 | PMID:15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/

RECORD: Rec_0394804 VERIFIED: YES

Provenance & Taxonomy

OrganismSevere acute respiratory syndrome-related coronavirus [Virus]

FamilyHR2-derived fusion inhibitor

Tax ID694009