Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length582 amino acids

Chemical FormulaC2829H4410N740O857S21

DescriptionStandard

        MSEGGPPCSLTSFPRPGRVARSRSKSDPCAFCRVVASAEWCKSGHHGVWEEKKLDLDKITRTRDQGTGIPQAREMSQIMSVRIQSELKSTAIPEVRDGIDIGIGTVDYDLSNMQVVECSMPDPSLVFVQGTGVSVTVSQLSLSVTGSWTTQFGIIHDGGSFDLAVYNIQIYTLLQLGDDAGRLSITTVSCSADIGGVDIQFHGVDVPVGQYIYLSIPLTSSPAVTDQSFELDIKGEFYSSSSPSEPPFSASVFDMQYAENSMLSLAASEFLVNSAAYAFLRSGVLQINIKDDMIPKSSPIHLNTSQFGAFIPQLRTLYPNMEMQVLLYASETPLFSFSSGVIDVHVPAAAKFSAVKPDGTLVPLFTLDVDCNFSGSALIDKNLTGAFEMKNLTLTLGSSEIGDFKTDSFQQVLVIAVKMFVLPKLNAALKIGFLLPTLQGFSLINSQLLIKNSSDIKCAVTVTSVCSHPKASSQDSHHPRASSKDGRLFARWPPPRHASEEDQWLIDFWSEPVLSSVPESAPESAPVPESASAHEPADPPKEIFWGGHIPVTPPWRPKLPVPPWRHPITLHLPTTSRVTAQE
    

Molecular Weight63173.09 Da

Isoelectric Point (pI)5.29

Net Charge (pH 7.0)-16.29

Net Charge (pH 7.4) -17.46

Charge Density (pH 7.0) -0.0280

GRAVY Index-0.04

Hydrophobic Moment 0.64

Boman Index0.11

Instability Index46.28

Aliphatic Index 86.75

Aromaticity 0.0808

Extinction Coeff. Reduced 64400.00

Extinction Coeff. Oxidized 64900.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0321278 VERIFIED: NO

Provenance & Taxonomy

OrganismAnabarilius grahami [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence