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MYP_034495
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Basic Information
CMK
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
4 amino acids
C23H47N11O5
Standard
Sequence
RVKR
Physicochemical Analysis
557.69 Da
12.00
2.76
2.55
0.6898
-2.17
1.14
-1.37
81.80
72.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
300.44
-2.84
12.0
8.0
20.0
39.0
0.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0275449 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Decanoyl(C10); chloromethylketone(CMK)
Bio-Activity Profile
Antiviral Anti-JEV Entry inhibition
Japanese encephalitis virus (JEV) | BHK-21 cells
19.91 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperDecanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. | Imran M, Saleemi MK, Chen Z, Wang X, Zhou D, Li Y, Zhao Z, Zheng B, Li Q, Cao S, Ye J. | Viruses. 2019 Oct 31;11(11):1011. | DOI:10.3390/v11111011 | PMID:31683742 PMID31683742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31683742/
RECORD: Rec_0277514 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus:SARS-CoV-2:inhibition of virus production in Vero E6 cells
0.057 μM
IC50
PMID23617302;31683742;33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
RECORD: Rec_0298842 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic
PMID23617302;31683742;33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
RECORD: Rec_0303059 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Decanoyl(C10); chloromethylketone(CMK)
Bio-Activity Profile
Antiviral Anti-HBV Entry inhibition
Hepatitis B virus (HBV) | HepG2.2.15 cells
100 μM
% inhibition
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperTherapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus. | Pang YJ, Tan XJ, Li DM, Zheng ZH, Lei RX, Peng XM. | Liver Int. 2013 Sep;33(8):1230-8. | DOI:10.1111/liv.12185 | PMID:23617302 PMID23617302 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
RECORD: Rec_0330087 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Decanoyl(C10); chloromethylketone(CMK)
Bio-Activity Profile
Antiviral Anti-ZIKV Entry inhibition
Zika virus (ZIKV) | Vero cells
18.59 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperDecanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. | Imran M, Saleemi MK, Chen Z, Wang X, Zhou D, Li Y, Zhao Z, Zheng B, Li Q, Cao S, Ye J. | Viruses. 2019 Oct 31;11(11):1011. | DOI:10.3390/v11111011 | PMID:31683742 PMID31683742 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31683742/
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