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MYP_034495
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Basic Information
CMK
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
4 amino acids
C23H47N11O5
Standard
Sequence
RVKR
Physicochemical Analysis
557.69 Da
12.00
2.76
2.55
0.6898
-2.17
1.14
-1.37
81.80
72.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
300.44
-2.84
12.0
8.0
20.0
39.0
0.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0128654 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic
Vero E6 cells:IC50=318
PMID23617302;31683742;33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
RECORD: Rec_0164003 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
PMID23617302;31683742;33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
RECORD: Rec_0173989 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Human hepatocellular carcinoma HepG2.2.15
PMID23617302;31683742;33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
RECORD: Rec_0181341 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus:Zika virus (ZIKV):inhibition of virus release in Vero cells
18.59 μM
IC50
PMID23617302;31683742;33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
RECORD: Rec_0250198 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Decanoyl(C10); chloromethylketone(CMK)
Bio-Activity Profile
Antiviral Anti-HBV Entry inhibition
Hepatitis B virus (HBV) | HepG2.2.15 cells
20 μM
% inhibition
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperTherapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus. | Pang YJ, Tan XJ, Li DM, Zheng ZH, Lei RX, Peng XM. | Liver Int. 2013 Sep;33(8):1230-8. | DOI:10.1111/liv.12185 | PMID:23617302 PMID23617302 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
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