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MYP_034495
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Basic Information
CMK
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
4 amino acids
C23H47N11O5
Standard
Sequence
RVKR
Physicochemical Analysis
557.69 Da
12.00
2.76
2.55
0.6898
-2.17
1.14
-1.37
81.80
72.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
300.44
-2.84
12.0
8.0
20.0
39.0
0.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015154 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus:Hepatitis B virus (HBV):Inhibition of HBeAg secretion in HepG2
PMID23617302;31683742;33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
RECORD: Rec_0018659 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Decanoyl(C10); chloromethylketone(CMK)
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2 | E6 cells
0.057 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperFurin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects. | Cheng YW, Chao TL, Li CL, Chiu MF, Kao HC, Wang SH, Pang YH, Lin CH, Tsai YM, Lee WH, Tao MH, Ho TC, Wu PY, Jang LT, Chen PJ, Chang SY, Yeh SH. | Cell Rep. 2020 Oct 13;33(2):108254. | DOI:10.1016/j.celrep.2020.108254 | PMID:33007239 PMID33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33007239/
RECORD: Rec_0039886 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Decanoyl(C10)
chloromethylketone(CMK)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic
Vero cells:CC50=712
PMID23617302;31683742;33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
RECORD: Rec_0052451 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Vero cells (50% Cell death at 712.9 , Vero E6 cells (50% Cytotoxicity at 318.2
6
Hemolysis
PMID23617302;31683742;33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
RECORD: Rec_0127130 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Hepatitis B virus
PMID23617302;31683742;33007239 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23617302/
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