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MYP_034426
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Basic Information
Eumenine mastoparan-AF (EMP-AF; Af-113; Insects, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
14 amino acids
C72H134N18O17
Standard
Sequence
INLLKIAKGIIKSL
Physicochemical Analysis
1523.94 Da
10.30
2.76
2.55
0.1969
1.06
0.69
0.31
-21.04
202.14
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
583.00
-2.07
20.0
20.0
56.0
107.0
0.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0399999 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0400469 VERIFIED: YES
Provenance & Taxonomy
Anterhynchium flavomarginatum micado [Animal]
MCD; Mastoparan subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Cytolytic Toxin Hemolytic
Staphylococcus aureus (Gram-positive)
PMID11006592;10775751;15317499;27096870;11053843;11342062 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11006592/
RECORD: Rec_0404958 VERIFIED: YES
Provenance & Taxonomy
Eumenine Anterhynchium flavomarginatum micado [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
human erythrocytes
100 μg/mL
Hemolysis
PMID34680789 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34680789/
RECORD: Rec_0405064 VERIFIED: YES
Provenance & Taxonomy
Anterhynchium flavomarginatum [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 6538
5 μg/mL
MIC
PMID15317499;11006592;10775751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15317499/
RECORD: Rec_0405425 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Toxic Cytotoxic
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
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