Peptide Database

Peptide NameBasic phospholipase A2 homolog 2 (svPLA2 homolog) (Myotoxin II) (MTX-II)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length121 amino acids

Chemical FormulaC594H949N169O172S15

DescriptionStandard

        SLFQLGKMILQETGKNPAASYGAYGCNCGVLGRGKPKDATDRCCYVHKCCKKKLTGCDPKKDRYSYSWKDKTIVCGENNPCLKELCECDKAVAICLRENLNTYNKKYRYHLKPFCKKADPC
    

Molecular Weight13690.89 Da

Isoelectric Point (pI)9.11

Net Charge (pH 7.0)11.49

Net Charge (pH 7.4) 10.92

Charge Density (pH 7.0) 0.0950

GRAVY Index-0.70

Hydrophobic Moment 0.52

Boman Index-0.18

Instability Index18.55

Aliphatic Index 57.27

Aromaticity 0.0909

Extinction Coeff. Reduced 17420.00

Extinction Coeff. Oxidized 18295.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5558.93

LogP -56.90

H-bond Donors 205.0

H-bond Acceptors 201.0

Rotatable Bonds 462.0

Heavy Atoms 950.0

Ring Count 20.0

Amide Bonds 129.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0019355 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops brazili [Animal]

FamilyPhospholipase A2; Group II subfamily; K49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Toxin Cytotoxic Non-hemolytic

TargetLeishmania

RECORD: Rec_0281313 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops brazili [Animal]

FamilyPhospholipase A2; Group II subfamily; K49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Toxin Cytotoxic Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0382787 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops brazili [Animal]

FamilyPhospholipase A2; Group II subfamily; K49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Toxin Cytotoxic Non-hemolytic

TargetCandida albicans