Peptide Database

Peptide NameSLAY-screened peptide P4997

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC102H170N32O26S2

DescriptionStandard

        SRTIRPCPRPCAIKIHYALE
    

Molecular Weight2324.77 Da

Isoelectric Point (pI)9.50

Net Charge (pH 7.0)2.53

Net Charge (pH 7.4) 2.24

Charge Density (pH 7.0) 0.1267

GRAVY Index-0.29

Hydrophobic Moment 0.77

Boman Index-0.14

Instability Index68.20

Aliphatic Index 88.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 928.24

LogP -7.72

H-bond Donors 35.0

H-bond Acceptors 32.0

Rotatable Bonds 71.0

Heavy Atoms 162.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0340298 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/