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MYP_034232
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Basic Information
Bradykinin
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Binding / Molecular interaction ▸ Binding activity
Cardiovascular
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
9 amino acids
C50H73N15O11
Standard
Sequence
RPPGFSPFR
Physicochemical Analysis
1060.21 Da
12.00
1.76
1.56
0.1956
-1.04
0.31
-0.22
121.91
0.00
0.2222
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
413.78
-3.57
14.0
13.0
27.0
76.0
5.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0385978 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0390592 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0403800 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Bradykinin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Myotropic Receptor modulation Immunomodulatory
smooth muscle
Experimental: 29±1 minutes; /1740 seconds; Mammalian: 1 hour; Yeast: 2 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Bradykinin (Mus musculus): PMID 9199253##8395230 PMID9199253;8395230 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9199253/
RECORD: Rec_0406337 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Bradykinin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Bronchodilatory Vasorelaxant Bradykinin receptor-modulating
PaperJ.M. Conlon et al. / General and Comparative Endocrinology 143 (2005) 193-199. Bradykinin-related peptides and tryptophyllins in the skin secretions of the most primitive extant frog, Ascaphus truei Evidence URLhttps://www.uniprot.org/uniprotkb/P84825/entry
RECORD: Rec_0407489 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Bradykinin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Myotropic Receptor modulation Immunomodulatory
Experimental: 29±1 minutes; /1740 seconds; Mammalian: 1 hour; Yeast: 2 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Bradykinin (Mus musculus): PMID 9199253##8395230 PMID9199253;8395230 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9199253/
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