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MYP_034224
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Basic Information
[Leu4] TG
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XGLLGGLXGIX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0067887 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X(1/4/8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: HeLa (Not active up to 20 μM)
PaperThe rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. Sci Rep. 2016 Apr 4;6:24000. doi: 10.1038/srep24000. PMID: 27039838. PMID27039838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27039838/
RECORD: Rec_0106584 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X(1/4/8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Bio-Activity Profile
Antimicrobial Anticancer
(Not active up to 20 μM)
PaperThe rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. Sci Rep. 2016 Apr 4;6:24000. doi: 10.1038/srep24000. PMID: 27039838. PMID27039838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27039838/
RECORD: Rec_0116946 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X(1)=TOAC; X(8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: HeLa (Not active up to 20 μM)
PaperThe rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. Sci Rep. 2016 Apr 4;6:24000. doi: 10.1038/srep24000. PMID: 27039838. PMID27039838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27039838/
RECORD: Rec_0208074 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X(1)=TOAC; X(8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperThe rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. Sci Rep. 2016 Apr 4;6:24000. doi: 10.1038/srep24000. PMID: 27039838. PMID27039838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27039838/
RECORD: Rec_0245993 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Oct (Fatty acid 1-Octanoyl)
None
X(1/4/8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperThe rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. Sci Rep. 2016 Apr 4;6:24000. doi: 10.1038/srep24000. PMID: 27039838. PMID27039838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27039838/
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