Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length186 amino acids

Chemical FormulaC945H1422N208O288S8

DescriptionStandard

        PMLIDDLAEVDYSLNSLPAVFQPFIDLDLKGIVYPSGNYTVPPYVASPFTIPDQSDSMLYLAFSEYFFQTYSFAYYAAGAFNTTIAEETCSYFNISTEIFGSIIPEVAKYSATPYPVMLKLMATEVPIISLEQDSFTVEIQGSMEVFAVLPDSTTQSLFTTNIAANTSIALNIFDQKVMGSLCLNR
    

Molecular Weight20561.14 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-15.04

Net Charge (pH 7.4) -15.17

Charge Density (pH 7.0) -0.0808

GRAVY Index0.30

Hydrophobic Moment 0.55

Boman Index0.26

Instability Index44.75

Aliphatic Index 92.31

Aromaticity 0.1398

Extinction Coeff. Reduced 17880.00

Extinction Coeff. Oxidized 18005.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7816.26

LogP -84.10

H-bond Donors 265.0

H-bond Acceptors 281.0

Rotatable Bonds 646.0

Heavy Atoms 1449.0

Ring Count 39.0

Amide Bonds 200.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0360287 VERIFIED: NO

Provenance & Taxonomy

OrganismCentropus unirufus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria