Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length471 amino acids

Chemical FormulaC2312H3664N586O683S16

DescriptionStandard

        MLLSVTVVLGLLSCVCGENPAVQVVLTNKGLQYGKHEAAGWIQERLSKITFPDITGSVHIIFGNVDYTLTGITIVKCDLPEPSVKFLQNPPGFQTTISDLSIAITGGWRTHFGIIHDGGTFDMAIYNVDVTSVVQLGKEPDGHPSVSSLSCHSQVGDVDIEFHGGASVIFQPFVKHFKGRIRDEIQKRLCPGVEGNIESFEDHLHVMNVSVDVNEVLTLALPLTDVPIIGASSVNVGLKGEFYNIKTPAEPPFEAQPFTMPDEPSYMLSVGMSDFTLNSASYAYFSAKLLQLLITDSMIPPISPVHLNTTSLGKFIPKLAEMYPDMLMSVLVHAQEAPKFSIQPDAVNASIKAVAKASVILPNGTQIPVFTINVDSKFSSELWIDDGKLKGSVKMDNVTLTLASSEVGTFKTDSLESLARTGGKFVLVKVNQKLREGFLVLRTKYAQLVNSVLKKEKGFLSISSDVQVLLT
    

Molecular Weight51110.38 Da

Isoelectric Point (pI)5.66

Net Charge (pH 7.0)-9.45

Net Charge (pH 7.4) -10.46

Charge Density (pH 7.0) -0.0201

GRAVY Index0.16

Hydrophobic Moment 0.68

Boman Index0.17

Instability Index36.74

Aliphatic Index 101.51

Aromaticity 0.0764

Extinction Coeff. Reduced 29910.00

Extinction Coeff. Oxidized 30160.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0147049 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis aureus (Israeli tilapia) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria