Peptide Database

Peptide NameSLAY-screened peptide P1047

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC113H154N26O31S

DescriptionStandard

        HNLTYTFLSSCPWVYSVSYH
    

Molecular Weight2404.65 Da

Isoelectric Point (pI)6.90

Net Charge (pH 7.0)-0.08

Net Charge (pH 7.4) -0.40

Charge Density (pH 7.0) -0.0039

GRAVY Index0.02

Hydrophobic Moment 0.26

Boman Index0.25

Instability Index55.54

Aliphatic Index 68.00

Aromaticity 0.2500

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 905.74

LogP -7.20

H-bond Donors 34.0

H-bond Acceptors 34.0

Rotatable Bonds 67.0

Heavy Atoms 171.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0232353 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/