Peptide Database

Peptide NameIr-Def2

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC185H282N58O46S6

DescriptionStandard

        GGYYCPFRQDKCHRHCRSFGRKAGYCGGFLKKTCICV
    

Molecular Weight4246.97 Da

Isoelectric Point (pI)9.46

Net Charge (pH 7.0)6.87

Net Charge (pH 7.4) 6.47

Charge Density (pH 7.0) 0.1857

GRAVY Index-0.51

Hydrophobic Moment 0.80

Boman Index-0.15

Instability Index55.23

Aliphatic Index 31.62

Aromaticity 0.1622

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1692.71

LogP -17.32

H-bond Donors 68.0

H-bond Acceptors 61.0

Rotatable Bonds 138.0

Heavy Atoms 295.0

Ring Count 9.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0433474 VERIFIED: YES

Provenance & Taxonomy

OrganismIxodes ricinus [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide5-26; 12-34; 16-36

Bio-Activity Profile

Function

Antimicrobial

TargetWest Nile virus (WNV)

Activity>100 μM

Methodvirus inhibition assay (no effect at 100 μM)

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