Peptide Database

Peptide NameE1P51-2

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC86H155N21O21S

DescriptionStandard

        RGVISLTPLLVCVAALLL
    

Molecular Weight1851.34 Da

Isoelectric Point (pI)8.25

Net Charge (pH 7.0)0.75

Net Charge (pH 7.4) 0.53

Charge Density (pH 7.0) 0.0417

GRAVY Index2.11

Hydrophobic Moment 0.41

Boman Index0.57

Instability Index0.54

Aliphatic Index 211.11

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 651.59

LogP -2.33

H-bond Donors 24.0

H-bond Acceptors 23.0

Rotatable Bonds 58.0

Heavy Atoms 129.0

Ring Count 1.0

Amide Bonds 17.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0200940 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAurein

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 NL4-3

Activity125 μM

MethodIC50

RECORD: Rec_0265311 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetVirus:HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells

Activity125 μM

MethodIC50

RECORD: Rec_0317300 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3 | TZM-bl cells

Activity125 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 2 min; E. coli: 2 min

PaperDefinition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor. | Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I. | Biochim Biophys Acta. 2016 Jun;1860(6):1139-48. | DOI:10.1016/j.bbagen.2016.02.008 | PMID:26905802 PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/