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MYP_033717
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Basic Information
Casein kappa [098-105]
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
8 amino acids
C46H62N14O10
Standard
Sequence
HPHPHLSF
Physicochemical Analysis
971.07 Da
7.02
0.02
-0.33
0.0027
-0.88
0.04
0.14
1.55
48.75
0.1250
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
355.71
-2.02
11.0
13.0
24.0
70.0
6.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0218172 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
28.9 μM
IC50
PaperAntihypertensive peptides: production, bioavailability and incorporation into foods. PMID21185549 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185549/
RECORD: Rec_0264356 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
kappa-Casein-derived
9940
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
28.9 μM
IC50
PaperChanges in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats | Miguel, M. et al. | DOI: 10.1002/mnfr.200900448 Evidence URLhttps://www.uniprot.org/uniprotkb/P02669/entry
RECORD: Rec_0294593 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Osteoanabolic
PaperReddi S., Shanmugam V. P., Tanedjeu K. S., Kapila S., Kapila R.. Effect of buffalo casein-derived novel bioactive peptides on osteoblast differentiation. Eur. J. Nutr., 57, 593-605, 2018.
RECORD: Rec_0308759 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0313271 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
kappa-Casein-derived
9940
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Osteoanabolic Bone-protective
PaperEffect of buffalo casein derived novel bioactive peptides on osteoblast differentiation | Reddi, S. et al. | DOI: 10.1007/s00394-016-1346-2 Evidence URLhttps://www.uniprot.org/uniprotkb/P02669/entry
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