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MYP_033717
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Basic Information
Casein kappa [098-105]
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
8 amino acids
C46H62N14O10
Standard
Sequence
HPHPHLSF
Physicochemical Analysis
971.07 Da
7.02
0.02
-0.33
0.0027
-0.88
0.04
0.14
1.55
48.75
0.1250
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
355.71
-2.02
11.0
13.0
24.0
70.0
6.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002066 VERIFIED: NO
Provenance & Taxonomy
Ovis aries [Animal] [Animal]; Bos taurus [Animal]
Casein-derived peptide
9940;9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide Antioxidant
RECORD: Rec_0025373 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
PaperG¨®mez-Ruiz J. ¨¢, Ramos M., Recio I.. Identification of novel angiotensin-converting enzyme-inhibitory peptides from ovine milk proteins by CE-MS and chromatographic techniques. Electrophoresis, 22, 4202-4211, 2007.
RECORD: Rec_0040911 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
28900 μM
IC50
PaperChanges in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats PMID20397194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20397194/
RECORD: Rec_0156648 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperG¨®mez-Ruiz J. ¨¢., L¨®pez-Exp¨®sito I., Pihlanto A., Ramos M., Recio I.. Antioxidant activity of ovine casein hydrolysates: identification of active peptides by HPLC-MS/MS. Eur. Food Res. Technol., 227, 1061-1067, 2008.
RECORD: Rec_0165988 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
15.7 mmHg
SBP decrease
PaperChanges in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats PMID20397194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20397194/
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