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MYP_033700
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Basic Information
Alpha-1-purothionin (Plant defensin)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
45 amino acids
C198H340N68O56S8
Standard
Sequence
KSCCRSTLGRNCYNLCRARGAQKLCAGVCRCKISSGLSCPKGFPK
Physicochemical Analysis
4825.76 Da
9.75
9.67
9.35
0.2150
-0.26
0.69
-0.19
39.54
56.44
0.0444
1490.00
1990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2036.62
-28.21
82.0
74.0
163.0
330.0
4.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000057 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Defensin
4565
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Cytotoxic
PaperPubMed PMID: 7824649 | PubMed PMID: 2235992 PMID7824649;2235992 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7824649/
RECORD: Rec_0067119 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Thionin
4565
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Toxin Anti-Gram-negative
Xanthomonas phaseoli
6 μg/mL
MIC
PMID9148105 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9148105/
RECORD: Rec_0067633 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
inoculum 1000, S. uvarum CC-23
<4 μg/mL
MIC
PaperInhibition of brewer's yeasts by wheat purothionins.
RECORD: Rec_0136921 VERIFIED: NO
Provenance & Taxonomy
Triticum vulgare [Plant]
Structure & Mods
disulfide-stabilized linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-39; 4-31; 12-29; 16-25
Bio-Activity Profile
Toxin
RECORD: Rec_0156111 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
inoculum 1000 and
32 μg/mL
MIC
PaperInhibition of brewer's yeasts by wheat purothionins.
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