Peptide Database

Peptide NameDermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme / Catalytic activity ▸ Protease

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length110 amino acids

Chemical FormulaC489H805N141O156S4

DescriptionStandard

        MRFMTLLFLTALAGALVCAYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL
    

Molecular Weight11283.73 Da

Isoelectric Point (pI)6.09

Net Charge (pH 7.0)-1.33

Net Charge (pH 7.4) -1.71

Charge Density (pH 7.0) -0.0121

GRAVY Index-0.22

Hydrophobic Moment 0.62

Boman Index0.02

Instability Index24.40

Aliphatic Index 86.18

Aromaticity 0.0273

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4724.89

LogP -53.10

H-bond Donors 161.0

H-bond Acceptors 161.0

Rotatable Bonds 382.0

Heavy Atoms 790.0

Ring Count 11.0

Amide Bonds 114.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0048743 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Proteolytic Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0071554 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Proteolytic Non-hemolytic

TargetEnterococcus faecalis (Gram-positive)

RECORD: Rec_0126634 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Proteolytic Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0415748 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Proteolytic Non-hemolytic

TargetCandida albicans