Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length469 amino acids

Chemical FormulaC2308H3627N587O673S22

DescriptionStandard

        MLPAVIVVLMLISFTRGENPAIQVILTRKGLQYGKHLGAGWVQEKLEHITLTDFSGEVLGIHYILTGITITKCDFPEPIVEFNPNNTGFTTSIAGLSVALTGGWMTHFGLIHDGGTFKMAIFGLDVTSVVELGKDPDGHLSVTSVSCDAQVGDVDIRFEGGASWIFQPFVEHFKGRMRGEIRSKICPNVEESIVSLDYHLQAMEVSIQVDEDLVLNIPLTGVPVIHASSMILGLKGEFYDRTHERPPFEAQNFTVPEQPDYMLSMGLSEFTVNSASYALYSGGRLQVLITDSMIPPYIHVRLNTSSMGPYVPQLPKMFPGLLMNLKVYASEVPMFSFQPGVVKLELAGAVKASAIEPNGTQIPLFKLNVDLTFDGKVWVAAGRLKGSMALQNLTLTLADSEVGHFETDTLESLVKMGVMAGLAKLNVELGKGVVLPRTRNAQLVNTVLGVEEGFIAMCSDAEVFTDSFN
    

Molecular Weight51071.44 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-17.42

Net Charge (pH 7.4) -18.40

Charge Density (pH 7.0) -0.0371

GRAVY Index0.21

Hydrophobic Moment 0.62

Boman Index0.20

Instability Index32.60

Aliphatic Index 99.89

Aromaticity 0.0832

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37150.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0313566 VERIFIED: NO

Provenance & Taxonomy

OrganismGymnodraco acuticeps [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria