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MYP_033586
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Basic Information
Sublancin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
37 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GLGKAQCAALWLQCASGGTIGXGGGAVACQNYRQFCR
Physicochemical Analysis
0.00 Da
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003580 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis subsp. subtilis str. 168 [Bacterium]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical or unresolved residue-containing peptide [Modified]
β-S-linked glucose at Cys22
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 10145
agar diffusion susceptibility assay (no activity)
PaperPaik SH, Chakicherla A, Hansen JN. Identification and characterization of ... sublancin 168 ... J Biol Chem. 1998;273:23134-23142. DOI:10.1074/jbc.273.36.23134. PMID:9722542. PMID9722542 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29854837/
RECORD: Rec_0010202 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis subsp. subtilis str. 168 [Bacterium]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical or unresolved residue-containing peptide [Modified]
β-S-linked glucose at Cys22
Bio-Activity Profile
Antimicrobial Antibacterial
Yersinia enterocolitica ATCC 23715
agar diffusion susceptibility assay (no activity)
PaperPaik SH, Chakicherla A, Hansen JN. Identification and characterization of ... sublancin 168 ... J Biol Chem. 1998;273:23134-23142. DOI:10.1074/jbc.273.36.23134. PMID:9722542. PMID9722542 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29854837/
RECORD: Rec_0052327 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis subsp. subtilis str. 168 [Bacterium]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical or unresolved residue-containing peptide [Modified]
β-S-linked glucose at Cys22
Bio-Activity Profile
Antimicrobial Antibacterial
Streptococcus pyogenes ATCC 49399
100 μg/mL
MIC
PaperPaik SH, Chakicherla A, Hansen JN. Identification and characterization of ... sublancin 168 ... J Biol Chem. 1998;273:23134-23142. DOI:10.1074/jbc.273.36.23134. PMID:9722542. PMID9722542 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29854837/
RECORD: Rec_0068672 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis subsp. subtilis str. 168 [Bacterium]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical or unresolved residue-containing peptide [Modified]
β-S-linked glucose at Cys22
Bio-Activity Profile
Antimicrobial Antibacterial
Murine macrophage cells RAW 264.7
macrophage activation, phagocytosis and MRSA-killing assay
PaperWang S et al. Enhancement of Macrophage Function by the Antimicrobial Peptide Sublancin Protects Mice from Methicillin-Resistant Staphylococcus aureus. J Immunol Res. 2019:3979352. DOI:10.1155/2019/3979352. PMID:31583256. PMID31583256 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29854837/
RECORD: Rec_0088421 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis subsp. subtilis str. 168 [Bacterium]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
β-S-linked glucose at Cys22
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
solution NMR spectroscopy
PaperGarcia De Gonzalo CV et al. NMR structure of the S-linked glycopeptide sublancin 168. ACS Chem Biol. 2014;9:796-801. DOI:10.1021/cb4008106. PMID:24405370. PDB:2MIJ. PMID24405370 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29854837/
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