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MYP_033569
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Basic Information
AHB2
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
75 amino acids
C399H633N109O128S3
Standard
Sequence
ELEEQVMHVLDQVSELAHELLHKLTGEELERAAYFNWWATEMMLELIKSDDEREIREIEEEARRILEHLEELARK
Physicochemical Analysis
9101.14 Da
4.56
-12.76
-13.17
-0.1702
-0.67
0.92
-0.14
58.98
102.80
0.0533
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3863.50
-26.53
133.0
122.0
320.0
639.0
10.0
77.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0082323 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Miniprotein inhibitor
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
0.0155 μM
IC50
PaperDe novo design of picomolar SARS-CoV-2 miniprotein inhibitors PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/
RECORD: Rec_0091339 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2
PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/
RECORD: Rec_0220836 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus:SARS-CoV-2:Inhibition of infection in Vero E6 cells
0.0155 μM
IC50
PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/
RECORD: Rec_0406899 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Binding inhibition
SARS-CoV-2 | E6 cells
0.0155 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperDe novo design of picomolar SARS-CoV-2 miniprotein inhibitors. | Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. | Science. 2020 Oct 23;370(6515):426-431. | DOI:10.1126/science.abd9909 | PMID:32907861 PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/