Peptide Database

Peptide NameSLAY-screened peptide P4355

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC97H147N27O31S

DescriptionStandard

        LYGNRCDQVIHVSDFPPTSA
    

Molecular Weight2219.43 Da

Isoelectric Point (pI)5.21

Net Charge (pH 7.0)-1.16

Net Charge (pH 7.4) -1.43

Charge Density (pH 7.0) -0.0581

GRAVY Index-0.26

Hydrophobic Moment 0.39

Boman Index0.05

Instability Index28.53

Aliphatic Index 73.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 930.92

LogP -10.52

H-bond Donors 32.0

H-bond Acceptors 32.0

Rotatable Bonds 66.0

Heavy Atoms 156.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0287826 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/