Peptide Database

Peptide NameSLAY-screened peptide P2519

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC72H94N14O18

DescriptionStandard

        SIDHSYLFWYI
    

Molecular Weight1443.60 Da

Isoelectric Point (pI)5.06

Net Charge (pH 7.0)-1.45

Net Charge (pH 7.4) -1.71

Charge Density (pH 7.0) -0.1321

GRAVY Index0.35

Hydrophobic Moment 0.06

Boman Index0.43

Instability Index9.09

Aliphatic Index 106.36

Aromaticity 0.3636

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 517.01

LogP -0.33

H-bond Donors 19.0

H-bond Acceptors 18.0

Rotatable Bonds 41.0

Heavy Atoms 104.0

Ring Count 6.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0332230 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/