Peptide Database

Peptide NameSLAY-screened peptide P4466

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC97H147N37O31S2

DescriptionStandard

        HNHLYHDTCTLNRRNCEAHG
    

Molecular Weight2391.56 Da

Isoelectric Point (pI)7.08

Net Charge (pH 7.0)0.09

Net Charge (pH 7.4) -0.35

Charge Density (pH 7.0) 0.0046

GRAVY Index-1.40

Hydrophobic Moment 0.41

Boman Index-0.33

Instability Index60.23

Aliphatic Index 44.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1119.30

LogP -14.72

H-bond Donors 41.0

H-bond Acceptors 37.0

Rotatable Bonds 76.0

Heavy Atoms 167.0

Ring Count 5.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0326604 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/