Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC80H121N15O18

DescriptionStandard

        VSFAIKWEYVLLL
    

Molecular Weight1580.91 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-0.27

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) -0.0204

GRAVY Index1.42

Hydrophobic Moment 0.23

Boman Index0.55

Instability Index2.70

Aliphatic Index 172.31

Aromaticity 0.2308

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 532.09

LogP 1.63

H-bond Donors 19.0

H-bond Acceptors 18.0

Rotatable Bonds 49.0

Heavy Atoms 113.0

Ring Count 4.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0384966 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HCV Entry inhibition

TargetHepatitis C virus(HCVpp) | hepatoma cells

Activity50 μM

Method% inhibition

Half-LifeMammalian: 100 h; Yeast: >20 h; E. coli: >10 h

PaperA peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry. | Liu R, Tewari M, Kong R, Zhang R, Ingravallo P, Ralston R. | Antiviral Res. 2010 May;86(2):172-9. | DOI:10.1016/j.antiviral.2010.02.316 | PMID:20156485 PMID20156485 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20156485/

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