Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length213 amino acids

Chemical FormulaC1044H1625N269O305S9

DescriptionStandard

        MLPSVMVVFAILSCTRGKNPAVQVTLTDKWLQYVKHVGAGWIQDKLEHITFPDISGDVDILIGHVYYTLSGIRITKCDLPEPVLEFFQSTGLKTSIVGLNAALVGNWRTSFGIIHDGGSFDMAIFSVSLTSMVQLGRDPDGHLSITSIGCEPQVGNVAIQFHGGASFIFQPFVDHFKGKIVSVIQSNICPNVQTAIDDLESHLQAMSSTTSSF
    

Molecular Weight23113.27 Da

Isoelectric Point (pI)5.66

Net Charge (pH 7.0)-5.82

Net Charge (pH 7.4) -6.54

Charge Density (pH 7.0) -0.0273

GRAVY Index0.28

Hydrophobic Moment 0.58

Boman Index0.22

Instability Index33.35

Aliphatic Index 99.67

Aromaticity 0.0892

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 21220.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0030814 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius pienaari [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria