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MYP_033219
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Basic Information
7R-Ahx-P3
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
18 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
RRRRRRRXGSLLGRMKGA
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0026932 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 8
Bio-Activity Profile
Antiviral
Hepatitis B virus (HBV)
8.6±3.2 μM
PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0049323 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Acp: epsilon-aminocaproic acid residue
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0101226 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 8 is 6-aminocaproic acid.
Bio-Activity Profile
Antiviral Anti-HBV
HBV | of cell; HepG2.2.15 cells
2.5±1 μM
EC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperArtificial recombinant cell-penetrating peptides interfere with envelopment of hepatitis B virus nucleocapsid and viral production. | Pan XB, Wei L, Han JC, Ma H, Deng K, Cong X. | Antiviral Res. 2011 Jan;89(1):109-14. | DOI:10.1016/j.antiviral.2010.12.001 | PMID:21144865 PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0150271 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 8
Bio-Activity Profile
Antiviral
Human hepatocellular carcinoma HepG2.2.15
287.5
IC50
PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0155246 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 8
Bio-Activity Profile
Antiviral
Hepatitis B virus (HBV)
2.5
EC50
PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
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