Peptide Database

Peptide NameProgonadoliberin-2

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Reproductive neuropeptide

Regulatory peptide ▸ Biological modulation

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length90 amino acids

Chemical FormulaC446H683N135O126S2

DescriptionStandard

        QHWSHGWYPGGKRALSSAQDPQNALRPPAGSPAQATYGLPSDALAHLEDSMPWEGRTMAWWSLRRKRYLAQTLLTAAREPRPVPPSSNKV
    

Molecular Weight10016.15 Da

Isoelectric Point (pI)10.26

Net Charge (pH 7.0)5.03

Net Charge (pH 7.4) 4.66

Charge Density (pH 7.0) 0.0559

GRAVY Index-0.81

Hydrophobic Moment 0.55

Boman Index-0.10

Instability Index76.94

Aliphatic Index 58.78

Aromaticity 0.0889

Extinction Coeff. Reduced 31970.00

Extinction Coeff. Oxidized 31970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4143.89

LogP -44.22

H-bond Donors 144.0

H-bond Acceptors 136.0

Rotatable Bonds 307.0

Heavy Atoms 709.0

Ring Count 27.0

Amide Bonds 96.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0324731 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca mulatta [Animal]

FamilyGnRH

Tax ID9544

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsGly10 Amidation

Bio-Activity Profile

Function

Hormone Reproductive neuropeptide

RECORD: Rec_0375177 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca mulatta [Animal]

FamilyProgonadoliberin

Tax ID9544

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Mods10:Glycine amide

Bio-Activity Profile

Function

Hormone Endocrine Reproductive regulator Receptor modulation

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0426093 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/