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MYP_032869
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Basic Information
Paenicidin A
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
36 amino acids
C139H234N42O50S6
Standard
Sequence
VLSIVACSSGCGSGKTAASCVETCGNRCFTNVGSLC
Physicochemical Analysis
3485.99 Da
7.75
0.68
0.37
0.0188
0.68
0.54
0.21
20.63
73.06
0.0278
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1475.29
-24.73
59.0
57.0
113.0
237.0
1.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0060677 VERIFIED: YES
Provenance & Taxonomy
Paenibacillus polymyxa [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
There are three lanthionines (between residues 3-7; 8-11; 19-24) and three methyllanthionines rings (between residues 16-20; 23-28; 30-36)
Bio-Activity Profile
Antimicrobial
Bacillus subtilis JH642 (++), E. faecium ATCC 19434 (+), L. lactis subsp. cremoris HP (++), Listeria monocytogenes ATCC 15313 (+), inactive at 100 uM: C.maltaromaticum UAL26, P.acidilactici PAC 1.0, Staphylococcus aureus ATCC 25923, Gram- C.jejuni 11168, Escherichia coli DH5alpha, Salmonella enterica serovar Typhimurium ATCC 13311
PaperStructural Characterization of the Highly Cyclized Lantibiotic Paenicidin A via a Partial Desulfurization/Reduction Strategy
RECORD: Rec_0079104 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 19.4%, E 0.0%, T 36.1%, C 44.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0250096 VERIFIED: YES
Provenance & Taxonomy
Paenibacillus polymyxa [Bacterium]; Bacteria [Bacterium]
1405; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID21262304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21262304/
RECORD: Rec_0319852 VERIFIED: YES
Provenance & Taxonomy
Paenibacillus polymyxa NRRL B-30509 [Bacterium]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23167271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23167271/
RECORD: Rec_0322036 VERIFIED: YES
Provenance & Taxonomy
Paenibacillus polymyxa [Bacterium]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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