Peptide Database

Peptide NameTemporin-GHd

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC76H108N18O16

DescriptionStandard

        FLQHIIGALSHFF
    

Molecular Weight1529.78 Da

Isoelectric Point (pI)6.92

Net Charge (pH 7.0)-0.07

Net Charge (pH 7.4) -0.37

Charge Density (pH 7.0) -0.0050

GRAVY Index1.21

Hydrophobic Moment 0.47

Boman Index0.59

Instability Index53.60

Aliphatic Index 127.69

Aromaticity 0.2308

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 533.20

LogP -1.03

H-bond Donors 18.0

H-bond Acceptors 18.0

Rotatable Bonds 47.0

Heavy Atoms 110.0

Ring Count 5.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0388648 VERIFIED: YES

Provenance & Taxonomy

OrganismHylarana guentheri [Animal]

FamilyTemporin

Tax ID110109

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Half-LifeHuman serum: about 95%remaining after 3 h

PaperDong Z, Luo W, Zhong H, Wang M, Song Y, Deng S, Zhang Y. Molecular cloning and characterization of antimicrobial peptides from skin of Hylarana guentheri. Acta Biochim Biophys Sin (Shanghai). 2017 May 1;49(5):450-457. PMID:28338958 https://pubmed.ncbi.nlm.nih.gov/28338958/ PMID28338958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28338958/

RECORD: Rec_0427112 VERIFIED: YES

Provenance & Taxonomy

OrganismHylarana guentheri [Animal]

FamilyTemporin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetStaphylococcus aureus ATCC 25923

Activity12.7 μM

MethodMIC

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