Peptide Database

Peptide NameKunitz-type serine protease inhibitor PIVL;

Function Ontology

Anticancer

Standard StatusStandard

Sequence Length60 amino acids

Chemical FormulaC297H442N88O89S7

DescriptionStandard

        QDRPKFCYLPADPAECNAYMPRFYYDSASNKCKEFIYGGCRGNANNFKNRAECRHTCVAS
    

Molecular Weight6893.68 Da

Isoelectric Point (pI)8.61

Net Charge (pH 7.0)2.79

Net Charge (pH 7.4) 2.43

Charge Density (pH 7.0) 0.0465

GRAVY Index-0.85

Hydrophobic Moment 0.54

Boman Index-0.20

Instability Index63.34

Aliphatic Index 29.50

Aromaticity 0.1500

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7825.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2894.82

LogP -33.46

H-bond Donors 105.0

H-bond Acceptors 100.0

Rotatable Bonds 219.0

Heavy Atoms 481.0

Ring Count 14.0

Amide Bonds 66.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0045309 VERIFIED: YES

Provenance & Taxonomy

OrganismMacrovipera lebetina [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Anticancer

Targetfibrinogen and 300 nM on fibronectin of glioblastoma cell line U87

Activity0.25 μM

MethodIC50