Peptide Database

Peptide NameR-spondin-1

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length243 amino acids

Chemical FormulaC1112H1822N376O344S25

DescriptionStandard

        SRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSRRRKGQQQQQQQGTVGPLTSAGPA
    

Molecular Weight26764.30 Da

Isoelectric Point (pI)9.44

Net Charge (pH 7.0)21.71

Net Charge (pH 7.4) 20.86

Charge Density (pH 7.0) 0.0893

GRAVY Index-0.90

Hydrophobic Moment 0.58

Boman Index-0.27

Instability Index78.88

Aliphatic Index 45.84

Aromaticity 0.0412

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 16845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0291935 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsAsparagine residue at position 117 is N-linked glycosylated; disulfide bonds between cysteine residues at positions 128 and 170; 139 and 146; 179 and 186

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetLGR4 (Human); LGR5 (Human); LGR6 (Human)

Activity0.02 nM

MethodEC50