Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length499 amino acids

Chemical FormulaC2542H3994N614O723S20

DescriptionStandard

        MLPGTESKGGGDITVSISGLFIAVIFKVSRDSTGHSSMFHRCQLSIYSLDLSFLSGYLENPIHTKLDKNLDLSFLSGYLENPIHTKLDKNDLKPDSLLLTAAKAVLDLCIIQKLFFDSKEVGLEILKQNMEKEGLPDLTGHEKFGPGNVKYNISRIRVTAVELPSASISLLPGMNWNIRTWMLYVQIRLSIKPLGTISDLLLMTVVLDPLIAFFLLSSFLHNFFIKYLKNPFTGAWSLITHKIISVVFVIFCVLSATFTAVMQIDDLAEVDYSSSSLPAGVVFPAGNYIDSPYEAASFTILDQSDSMLYLTSLFAYYTTGSNLVTHLFSLFYFFLPTCSYFNINTEIFGSIISEIMMLKLMSAEIPVISLQQNSFMLEIRGSMEVLAVLQDSTTQSLLTLSIAANTSISLNVFNKKLMGSLCLNRIQFSLAHSNVGSFEVLPLENILSYILETEVIPSANAKLSKGFPLPNLANVTLTRPHITIVQGYMLISADVHYKH
    

Molecular Weight55365.88 Da

Isoelectric Point (pI)5.84

Net Charge (pH 7.0)-7.46

Net Charge (pH 7.4) -8.47

Charge Density (pH 7.0) -0.0150

GRAVY Index0.39

Hydrophobic Moment 0.57

Boman Index0.23

Instability Index33.28

Aliphatic Index 113.89

Aromaticity 0.1022

Extinction Coeff. Reduced 41830.00

Extinction Coeff. Oxidized 42080.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0342366 VERIFIED: NO

Provenance & Taxonomy

OrganismZosterops borbonicus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence