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MYP_032794
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Basic Information
Alloferon [H1PHE(4-OMe)]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XGVSGHGQHGVHG
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044805 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 1 indicates 4-Methoxy-phenylalanine
Bio-Activity Profile
Antimicrobial Antiviral
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0074737 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 1 indicates 4-Methoxy-phenylalanine
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
toxic against Vero cells up to 312 μM
312 μM
Cytotoxicity
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0171371 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 1 indicates 4-Methoxy-phenylalanine
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0171474 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 1 indicates 4-Methoxy-phenylalanine
Bio-Activity Profile
Antimicrobial Antiviral
Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Vero cells
220 μM
IC50
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0175351 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 1 indicates 4-Chloro-phenylalanine
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
toxic against Vero cells up to 255 μM
255 μM
Cytotoxicity
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
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